Ethanol Impairs Estrogen Receptor Signaling Resulting in Accelerated Activation of Senescence Pathways, Whereas Estradiol Attenuates the Effects of Ethanol in Osteoblasts

Epidemiological and animal studies have suggested that chronic alcohol consumption is a major risk factor for osteoporosis. Using bone from cycling female rats infused chronically with ethanol (EtOH) in vivo and osteoblastic cells in vitro, we found that EtOH significantly increased estrogen recepto...

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Hlavní autoři: Chen, Jin-Ran, Lazarenko, Oxana P, Haley, Rani Lynn, Blackburn, Michael L, Badger, Thomas M, Ronis, Martin J
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons and The American Society for Bone and Mineral Research (ASBMR) 2009
Témata:
Research-Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3276356/
https://ncbi.nlm.nih.gov/pubmed/18847333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1359/jbmr.081011
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