Transient Overexpression of Sonic Hedgehog Alters the Architecture and Mechanical Properties of Trabecular Bone

Bone formation and remodeling involve coordinated interactions between osteoblasts and osteoclasts through signaling networks involving a variety of molecular pathways. We hypothesized that overexpression of Sonic hedgehog (Shh), a morphogen with a crucial role in skeletal development, would stimula...

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Bibliographic Details
Main Authors: Kiuru, Maija, Solomon, Jason, Ghali, Bassem, van der Meulen, Marjolein, Crystal, Ronald G, Hidaka, Chisa
Format: Artigo
Language:Inglês
Published: John Wiley and Sons and The American Society for Bone and Mineral Research (ASBMR) 2009
Subjects:
Research-Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3276343/
https://ncbi.nlm.nih.gov/pubmed/19338448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1359/jbmr.090313
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