CREB-activity and nmnat2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy

Tauopathies, characterized by neurofibrillary tangles (NFTs) of phosphorylated tau proteins, are a group of neurodegenerative diseases, including frontotemporal dementia and both sporadic and familial Alzheimer's disease. Forebrain-specific over-expression of human tau(P301L), a mutation associ...

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Detaylı Bibliyografya
Asıl Yazarlar: Ljungberg, M. Cecilia, Ali, Yousuf O., Zhu, Jie, Wu, Chia-Shan, Oka, Kazuhiro, Zhai, R. Grace, Lu, Hui-Chen
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2012
Konular:
Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3276285/
https://ncbi.nlm.nih.gov/pubmed/22027994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr492
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