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Significance analysis and statistical dissection of variably methylated regions

It has recently been proposed that variation in DNA methylation at specific genomic locations may play an important role in the development of complex diseases such as cancer. Here, we develop 1- and 2-group multiple testing procedures for identifying and quantifying regions of DNA methylation varia...

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Detalhes bibliográficos
Main Authors: Jaffe, Andrew E., Feinberg, Andrew P., Irizarry, Rafael A., Leek, Jeffrey T.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3276267/
https://ncbi.nlm.nih.gov/pubmed/21685414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/biostatistics/kxr013
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