‘Chromosomal Rainbows’ Detect Oncogenic Rearrangements of Signaling Molecules in Thyroid Tumors

Altered signal transduction can be considered a hallmark of many solid tumors. In thyroid cancers the receptor tyrosine kinase (rtk) genes NTRK1 (Online Mendelian Inheritance in Man = OMIM *191315, also known as ‘TRKA’), RET (‘Rearranged during Transfection protooncogene’, OMIM *164761) and MET (OMI...

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Main Authors: O’Brien, Benjamin, Jossart, Gregg H., Ito, Yuko, Greulich-Bode, Karin M., Weier, Jingly F., Munne, Santiago, Clark, Orlo H., Weier, Heinz-Ulrich G.
Format: Artigo
Language:Inglês
Published: 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3276079/
https://ncbi.nlm.nih.gov/pubmed/22328910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2172/1011038
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