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Intrinsic contribution of the 2′-hydroxyl to RNA conformational heterogeneity
Canonical duplex RNA assumes only the A-form conformation at the secondary structure level while, in contrast, a wide range of non-canonical, tertiary conformations of RNA occur. Here, we show how the 2′-hydroxyl controls RNA conformational properties. Quantum mechanical (QM) calculations reveal tha...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3275647/ https://ncbi.nlm.nih.gov/pubmed/22242623 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja211328g |
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