Long-Term Gene Therapy Causes Transgene-Specific Changes in the Morphology of Regenerating Retinal Ganglion Cells

Recombinant adeno-associated viral (rAAV) vectors can be used to introduce neurotrophic genes into injured CNS neurons, promoting survival and axonal regeneration. Gene therapy holds much promise for the treatment of neurotrauma and neurodegenerative diseases; however, neurotrophic factors are known...

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Bibliographic Details
Main Authors: Rodger, Jennifer, Drummond, Eleanor S., Hellström, Mats, Robertson, Donald, Harvey, Alan R.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3275572/
https://ncbi.nlm.nih.gov/pubmed/22347429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031061
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