Genomic complexity and AKT dependence in serous ovarian cancer

Effective oncoprotein-targeted therapies have not yet been developed for ovarian cancer. To explore the role of PI3 kinase/AKT signaling in this disease, we performed a genetic and functional analysis of ovarian cancer cell lines and tumors. PI3K pathway alterations were common in both, but the spec...

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Detalhes bibliográficos
Main Authors: Hanrahan, Aphrothiti J., Schultz, Nikolaus, Westfal, Maggie L., Sakr, Rita A., Giri, Dilip D., Scarperi, Stefano, Janikariman, Manickam, Olvera, Narciso, Stevens, Ellen V., She, Qing-Bai, Aghajanian, Carol, King, Tari A., Stanchina, Elisa de, Spriggs, David R., Heguy, Adriana, Taylor, Barry S., Sander, Chris, Rosen, Neal, Levine, Douglas A., Solit, David B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3274821/
https://ncbi.nlm.nih.gov/pubmed/22328975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-11-0170
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