A Hot-Spot Motif Characterizes the Interface between a Designed Ankyrin-Repeat Protein and Its Target Ligand

Nonantibody scaffolds such as designed ankyrin repeat proteins (DARPins) can be rapidly engineered to detect diverse target proteins with high specificity and offer an attractive alternative to antibodies. Using molecular simulations, we predicted that the binding interface between DARPin off7 and i...

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Main Authors: Cheung, Luthur Siu-Lun, Kanwar, Manu, Ostermeier, Marc, Konstantopoulos, Konstantinos
Formato: Artigo
Idioma:Inglês
Publicado: The Biophysical Society 2012
Assuntos:
Biological Systems and Multicellular Dynamics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3274810/
https://ncbi.nlm.nih.gov/pubmed/22325262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.01.004
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