A Hot-Spot Motif Characterizes the Interface between a Designed Ankyrin-Repeat Protein and Its Target Ligand

Nonantibody scaffolds such as designed ankyrin repeat proteins (DARPins) can be rapidly engineered to detect diverse target proteins with high specificity and offer an attractive alternative to antibodies. Using molecular simulations, we predicted that the binding interface between DARPin off7 and i...

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Main Authors: Cheung, Luthur Siu-Lun, Kanwar, Manu, Ostermeier, Marc, Konstantopoulos, Konstantinos
格式: Artigo
語言:Inglês
出版: The Biophysical Society 2012
主題:
Biological Systems and Multicellular Dynamics
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3274810/
https://ncbi.nlm.nih.gov/pubmed/22325262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.01.004
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