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Effect of Sequence Variation on the Mechanical Response of Amyloid Fibrils Probed by Steered Molecular Dynamics Simulation

The mechanical failure of mature amyloid fibers produces fragments that act as seeds for the growth of new fibrils. Fragmentation may also be correlated with cytotoxicity. We have used steered atomistic molecular dynamics simulations to study the mechanical failure of fibrils formed by the amyloidog...

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Bibliografiset tiedot
Päätekijät: Ndlovu, Hlengisizwe, Ashcroft, Alison E., Radford, Sheena E., Harris, Sarah A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The Biophysical Society 2012
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Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3274783/
https://ncbi.nlm.nih.gov/pubmed/22325282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.12.047
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