Redox Modification of Ryanodine Receptors Contributes to Sarcoplasmic Reticulum Ca(2+) Leak in Chronic Heart Failure

Abnormal cardiac ryanodine receptor (RyR2) function is recognized as an important factor in the pathogenesis of heart failure (HF). However, the specific molecular causes underlying RyR2 defects in HF remain poorly understood. In the present study, we used a canine model of chronic HF to test the hy...

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Autors principals: Terentyev, Dmitry, Györke, Inna, Belevych, Andriy E., Terentyeva, Radmila, Sridhar, Arun, Nishijima, Yoshinori, de Blanco, Esperanza Carcache, Khanna, Savita, Sen, Chandan K., Cardounel, Arturo J., Carnes, Cynthia A., Györke, Sandor
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3274754/
https://ncbi.nlm.nih.gov/pubmed/19008475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.108.184457
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