Redox Modification of Ryanodine Receptors Contributes to Sarcoplasmic Reticulum Ca(2+) Leak in Chronic Heart Failure

Abnormal cardiac ryanodine receptor (RyR2) function is recognized as an important factor in the pathogenesis of heart failure (HF). However, the specific molecular causes underlying RyR2 defects in HF remain poorly understood. In the present study, we used a canine model of chronic HF to test the hy...

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Hlavní autoři: Terentyev, Dmitry, Györke, Inna, Belevych, Andriy E., Terentyeva, Radmila, Sridhar, Arun, Nishijima, Yoshinori, de Blanco, Esperanza Carcache, Khanna, Savita, Sen, Chandan K., Cardounel, Arturo J., Carnes, Cynthia A., Györke, Sandor
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3274754/
https://ncbi.nlm.nih.gov/pubmed/19008475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.108.184457
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