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The interaction of the von Hippel-Lindau tumor suppressor and heterochromatin protein 1
Inactivation of the von Hippel-Lindau (VHL) tumor suppressor is associated with renal carcinoma, hemangioblastoma and pheochromocytoma. The VHL protein is a component of a ubiquitin ligase complex that ubiquitinates and degrades hypoxia inducible factor-α (HIF-α). Degradation of HIF-α by VHL is prop...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2012
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3274591/ https://ncbi.nlm.nih.gov/pubmed/22234250 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2011.12.023 |
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