Alternaria-Induced Release of IL-18 from Damaged Airway Epithelial Cells: An NF-κB Dependent Mechanism of Th2 Differentiation?

BACKGROUND: A series of epidemiologic studies have identified the fungus Alternaria as a major risk factor for asthma. The airway epithelium plays a critical role in the pathogenesis of allergic asthma. These reports suggest that activated airway epithelial cells can produce cytokines such as IL-25,...

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Detalhes bibliográficos
Main Authors: Murai, Hiroki, Qi, Huibin, Choudhury, Barun, Wild, Jim, Dharajiya, Nilesh, Vaidya, Swapnil, Kalita, Anjana, Bacsi, Attila, Corry, David, Kurosky, Alexander, Brasier, Allan, Boldogh, Istvan, Sur, Sanjiv
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3274547/
https://ncbi.nlm.nih.gov/pubmed/22347372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030280
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