The Thermal Structural Transition of Alpha-Crystallin Modulates Subunit Interactions and Increases Protein Solubility

BACKGROUND: Alpha crystallin is an oligomer composed of two types of subunits, alpha-A and alpha-B crystallin, and is the major constituent of human lens. The temperature induced condensation of alpha-crystallin, the main cause for eye lens opacification (cataract), is a two step-process, a nucleati...

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Bibliografiske detaljer
Main Authors: Maulucci, Giuseppe, De Spirito, Marco, Arcovito, Giuseppe, Papi, Massimiliano
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3274527/
https://ncbi.nlm.nih.gov/pubmed/22347398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030705
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