Decoupling of Tumor-Initiating Activity from Stable Immunophenotype In HoxA9-Meis1 Driven AML

Increasing evidence suggests tumors are maintained by cancer stem cells; however, their nature remains controversial. In a HoxA9-Meis1 (H9M) model of acute myeloid leukemia (AML), we found that tumor-initiating activity existed in three, immunophenotypically distinct compartments, corresponding to d...

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Bibliografiske detaljer
Main Authors: Gibbs, Kenneth D., Jager, Astraea, Crespo, Oliver, Goltsev, Yury, Trejo, Angelica, Richard, Chase E., Nolan, Garry P.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3273989/
https://ncbi.nlm.nih.gov/pubmed/22305570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2012.01.004
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