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Natural variation in a chloride channel subunit confers avermectin resistance in C. elegans
Resistance of nematodes to anthelmintics such as avermectins has emerged as a major global health and agricultural problem, but genes conferring natural resistance to avermectins are unknown. We show that a naturally occurring four amino-acid deletion in the ligand-binding domain of GLC-1, the alpha...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3273849/ https://ncbi.nlm.nih.gov/pubmed/22301316 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1214318 |
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