R-loop-mediated genome instability in mRNA cleavage and polyadenylation mutants

Genome instability via RNA:DNA hybrid-mediated R loops has been observed in mutants involved in various aspects of transcription and RNA processing. The prevalence of this mechanism among essential chromosome instability (CIN) genes remains unclear. In a secondary screen for increased Rad52 foci in...

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Detalhes bibliográficos
Main Authors: Stirling, Peter C., Chan, Yujia A., Minaker, Sean W., Aristizabal, Maria J., Barrett, Irene, Sipahimalani, Payal, Kobor, Michael S., Hieter, Philip
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2012
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3273840/
https://ncbi.nlm.nih.gov/pubmed/22279048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.179721.111
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