Dengue Hemorrhagic Fever-Associated Immunomediators Induced via Maturation of Dengue Virus Nonstructural 4B Protein in Monocytes Modulate Endothelial Cell Adhesion Molecules and Human Microvascular Endothelial Cells Permeability

We previously demonstrated that dengue virus (DENV) nonstructural 4B protein (NS4B) induced dengue hemorrhagic fever (DHF)-associated immunomediators in THP-1 monocytes. Moreover, cleavage of NS4AB polyprotein by the NS2B3 protease, significantly increased immunomediator production to levels found a...

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Päätekijät: Kelley, James F., Kaufusi, Pakieli H., Nerurkar, Vivek R.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2011
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3273497/
https://ncbi.nlm.nih.gov/pubmed/22129847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2011.10.030
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