hMLH1 promoter methylation and silencing in primary endometrial cancers are associated with specific alterations in MBDs occupancy and histone modifications

OBJECTIVE: To investigate the relationship between hMLH1 promoter methylation and changes in chromatin composition. To study how the occupancy of methyl CpG binding domain proteins (MBDs) and histone acetylation/methylation in hMLH1 promoter may participate in hMLH1 silencing. METHODS: 64 endometria...

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Detaylı Bibliyografya
Asıl Yazarlar: Xiong, Yuning, Dowdy, Sean C., Eberhardt, Norman L., Podratz, Karl C., Jiang, Shi-Wen
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2006
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3273419/
https://ncbi.nlm.nih.gov/pubmed/16701802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2006.03.045
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