The reactions of thiouridines and thiouracils with chloroacetaldehyde; mechanistic considerations.

2-Thiouridine, 4-thiouridine and the corresponding thiouracils were quantitatively modified with aqueous chloroacetaldehyde /37 degrees C, pH 3.0--6.5/. The rate-pH dependence found for the disappearance of the substrates suggested initial S-alkylation. The unstable S-acetaldehydyl intermediates wer...

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Pubblicato in:	Nucleic Acids Res
Autori principali:	Krzyzosiak, W J, Biernat, J, Ciesiołka, J, Górnicki, P, Wiewiórowski, M
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Oxford University Press 1980
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC327317/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7433118/
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