Mannose 6 Dephosphorylation of Lysosomal Proteins Mediated by Acid Phosphatases Acp2 and Acp5

Mannose 6-phosphate (Man6P) residues represent a recognition signal required for efficient receptor-dependent transport of soluble lysosomal proteins to lysosomes. Upon arrival, the proteins are rapidly dephosphorylated. We used mice deficient for the lysosomal acid phosphatase Acp2 or Acp5 or lacki...

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Huvudupphovsmän: Makrypidi, Georgia, Damme, Markus, Müller-Loennies, Sven, Trusch, Maria, Schmidt, Bernhard, Schlüter, Hartmut, Heeren, Joerg, Lübke, Torben, Saftig, Paul, Braulke, Thomas
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2012
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Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3272978/
https://ncbi.nlm.nih.gov/pubmed/22158965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.06195-11
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