Quantitative Proteome Analysis of Mouse Liver Lysosomes Provides Evidence for Mannose 6-phosphate-independent Targeting Mechanisms of Acid Hydrolases in Mucolipidosis II

The efficient receptor-mediated targeting of soluble lysosomal proteins to lysosomes requires the modification with mannose 6-phosphate (M6P) residues. Although the absence of M6P results in misrouting and hypersecretion of lysosomal enzymes in many cells, normal levels of lysosomal enzymes have bee...

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Detalhes bibliográficos
Publicado no:Mol Cell Proteomics
Main Authors: Markmann, Sandra, Krambeck, Svenja, Hughes, Christopher J., Mirzaian, Mina, Aerts, Johannes M.F.G., Saftig, Paul, Schweizer, Michaela, Vissers, Johannes P.C., Braulke, Thomas, Damme, Markus
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5341004/
https://ncbi.nlm.nih.gov/pubmed/28062798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M116.063636
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