Solution structure of CCL21 and identification of a putative CCR7 binding site

CCL21 is a human chemokine that recruits normal immune cells and metastasizing tumor cells to lymph nodes through activation of the G protein-coupled receptor CCR7. The CCL21 structure solved by NMR contains a conserved chemokine domain followed by an extended, unstructured C-terminus that is not ty...

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Bibliographic Details
Main Authors:	Love, Melissa, Sandberg, Jamie L., Ziarek, Joshua J., Gerarden, Kyle P., Rode, Renee R., Jensen, Davin R., McCaslin, Darrell R., Peterson, Francis C., Veldkamp, Christopher T.
Format:	Artigo
Language:	Inglês
Published:	2012
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3272885/ https://ncbi.nlm.nih.gov/pubmed/22221265 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201601k
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Solution structure of CCL21 and identification of a putative CCR7 binding site

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