Modification of the Early Gene Enhancer-promoter Improves the Oncolytic Potency of Adenovirus 11

Oncolytic adenoviruses based on serotype 5 (Ad5) have several shortcomings, including the downregulation of its receptor in cancer cells, high prevalence of neutralizing antibodies and hepatotoxicity. Another adenoviral serotype, Ad11, could overcome these obstacles. Here, we show that human cancer...

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Bibliografiske detaljer
Main Authors: Wong, Han Hsi, Jiang, Guozhong, Gangeswaran, Rathi, Wang, Pengju, Wang, Jiwei, Yuan, Ming, Wang, Hexiao, Bhakta, Vipul, Müller, Heike, Lemoine, Nicholas R, Wang, Yaohe
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2012
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3272483/
https://ncbi.nlm.nih.gov/pubmed/22086234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.242
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