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Anticancer Activity of an Imageable Curcuminoid 1-[2-Aminoethyl-(6-hydrazinopyridine-3-carbamidyl)-3,5-bis-(2-fluorobenzylidene)-4-piperidone (EFAH)
3,5-bis(2-fluorobenzylidine)-4-piperidone or EF24 is a potent anticancer derivative of curcumin. Using an amine derivative of EF24, we synthesized a hydrazinonicotinic acid conjugate, EFAH, for Tc-99m radiolabeling and SPECT imaging. The aqueous solubility of EFAH (3.5 mg/ml) was significantly more...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2011
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3272321/ https://ncbi.nlm.nih.gov/pubmed/22107757 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1747-0285.2011.01271.x |
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