Noradrenergic α(1) Receptor Antagonist Treatment Attenuates Positive Subjective Effects of Cocaine in Humans: A Randomized Trial

BACKGROUND: Preclinical research implicates dopaminergic and noradrenergic mechanisms in mediating the reinforcing effects of drugs of abuse, including cocaine. The objective of this study was to evaluate the impact of treatment with the noradrenergic α(1) receptor antagonist doxazosin on the positi...

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Autori principali: Newton, Thomas F., De La Garza, Richard, Brown, Gregory, Kosten, Thomas R., Mahoney, James J., Haile, Colin N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3272014/
https://ncbi.nlm.nih.gov/pubmed/22319592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030854
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