Assurance of mitochondrial integrity and mammalian longevity by the p62–Keap1–Nrf2–Nqo1 cascade

Sqstm1/p62 functions in the non-canonical activation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2). However, its physiological relevance is not certain. Here, we show that p62(−/−) mice exhibited an accelerated presentation of ageing phenotypes, and tissues from these mice created a pro-oxid...

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Hlavní autoři: Kwon, Jeongho, Han, Eunhye, Bui, Chi-Bao, Shin, Woochul, Lee, Junho, Lee, Sejeong, Choi, Young-Bong, Lee, Ann-Hwee, Lee, Kyong-Hoon, Park, Chankyu, Obin, Martin S, Park, Sung Kyu, Seo, Yun Jeong, Oh, Goo Taeg, Lee, Han-Woong, Shin, Jaekyoon
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2012
Témata:
Scientific Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3271336/
https://ncbi.nlm.nih.gov/pubmed/22222206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2011.246
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