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Enantioselective Total Synthesis of (−) - Acetylaranotin, A Dihydrooxepine Epidithiodiketopiperazine

The first total synthesis of the dihydrooxepine-containing epidithiodiketopiperazine (ETP) (−)-acetylaranotin (1) is reported. The key steps of the synthesis include an enantioselective azomethine ylide (1, 3)-dipolar cycloaddition reaction to set the absolute and relative stereochemistry, a rhodium...

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Bibliografiske detaljer
Main Authors: Codelli, Julian A., Puchlopek, Angela L. A., Reisman, Sarah E.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3271125/
https://ncbi.nlm.nih.gov/pubmed/22023250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja209354e
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