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Short Isoforms of the Cold Receptor TRPM8 Inhibit Channel Gating by Mimicking Heat Action Rather than Chemical Inhibitors

Transient receptor potential (TRP) channels couple various environmental factors to changes in membrane potential, calcium influx, and cell signaling. They also integrate multiple stimuli through their typically polymodal activation. Thus, although the TRPM8 channel has been extensively investigated...

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Detalhes bibliográficos
Main Authors: Fernández, José A., Skryma, Roman, Bidaux, Gabriel, Magleby, Karl L., Scholfield, C. Norman, McGeown, J. Graham, Prevarskaya, Natalia, Zholos, Alexander V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3270953/
https://ncbi.nlm.nih.gov/pubmed/22128172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.272823
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