Transforming Growth Factor-β Protein Inversely Regulates in Vivo Differentiation of Interleukin-17 (IL-17)-producing CD4(+) and CD8(+) T Cells

TGF-β is a pleiotropic cytokine that predominantly exerts inhibitory functions in the immune system. Unexpectedly, the in vitro differentiation of both Th17 and Tc17 cells requires TGF-β. However, animals that are impaired in TGF-β signaling (TGF-βRIIDN mice) display multiorgan autoimmune disorders....

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Main Authors: Dwivedi, Ved Prakash, Tousif, Sultan, Bhattacharya, Debapriya, Prasad, Durbaka Vijay Raghva, Van Kaer, Luc, Das, Jyoti, Das, Gobardhan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
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Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3270951/
https://ncbi.nlm.nih.gov/pubmed/22170065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C111.327627
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