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Evolutionary Diversification of Mesobuthus α-Scorpion Toxins Affecting Sodium Channels

α-Scorpion toxins constitute a family of peptide modulators that induce a prolongation of the action potential of excitable cells by inhibiting voltage-gated sodium channel inactivation. Although they all adopt a conserved structural scaffold, the potency and phylogentic preference of these toxins l...

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Autores principales: Zhu, Shunyi, Peigneur, Steve, Gao, Bin, Lu, Xiuxiu, Cao, Chunyang, Tytgat, Jan
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Biochemistry and Molecular Biology 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3270107/
https://ncbi.nlm.nih.gov/pubmed/21969612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M111.012054
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