Sublingual immunization with adenovirus F protein-based vaccines stimulates protective immunity against botulinum neurotoxin A intoxication

Sublingual (s.l.) vaccination is an efficient way to induce elevated levels of systemic and mucosal immune responses. To mediate mucosal uptake, ovalbumin (OVA) was genetically fused to adenovirus 2 fiber protein (OVA-Ad2F) to assess whether s.l. immunization was as effective as an alternative route...

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Bibliographic Details
Main Authors: Jun, SangMu, Clapp, Beata, Zlotkowska, Dagmara, Hoyt, Teri, Holderness, Kathryn, Maddaloni, Massimo, Pascual, David W.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2012
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Original Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3270090/
https://ncbi.nlm.nih.gov/pubmed/22207133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/intimm/dxr106
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