Coronavirus Papain-like Proteases Negatively Regulate Antiviral Innate Immune Response through Disruption of STING-Mediated Signaling

Viruses have evolved elaborate mechanisms to evade or inactivate the complex system of sensors and signaling molecules that make up the host innate immune response. Here we show that human coronavirus (HCoV) NL63 and severe acute respiratory syndrome (SARS) CoV papain-like proteases (PLP) antagonize...

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Detalhes bibliográficos
Main Authors: Sun, Li, Xing, Yaling, Chen, Xiaojuan, Zheng, Yang, Yang, Yudong, Nichols, Daniel B., Clementz, Mark A., Banach, Bridget S., Li, Kui, Baker, Susan C., Chen, Zhongbin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3270028/
https://ncbi.nlm.nih.gov/pubmed/22312431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030802
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