In Vivo Topoisomerase I Inhibition Attenuates the Expression of Hypoxia-Inducible Factor 1α Target Genes and Decreases Tumor Angiogenesis

Topoisomerase I is a privileged target for widely used anticancer agents such as irinotecan. Although these drugs are classically considered to be DNA-damaging agents, increasing evidence suggests that they might also influence the tumor environment. This study evaluates in vivo cellular and molecul...

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Detalhes bibliográficos
Main Authors: Guérin, Eric, Raffelsberger, Wolfgang, Pencreach, Erwan, Maier, Armin, Neuville, Agnès, Schneider, Anne, Bachellier, Philippe, Rohr, Serge, Petitprez, Amélie, Poch, Olivier, Moras, Dino, Oudet, Pierre, Larsen, Annette K, Gaub, Marie-Pierre, Guenot, Dominique
Formato: Artigo
Idioma:Inglês
Publicado em: ScholarOne 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3269639/
https://ncbi.nlm.nih.gov/pubmed/22033674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2011.00120
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