Transplacental Carcinogenesis with Dibenzo[def,p]chrysene (DBC): Timing of Maternal Exposures Determines Target Tissue Response in Offspring

Dibenzo[def,p]chrysene (DBC) is a transplacental carcinogen in mice (15 mg/kg; gestation day (GD) 17). To mimic residual exposure throughout pregnancy, dams received 4 smaller doses of DBC (3.75 mg/kg) on GD 5, 9, 13 and 17. This regimen alleviated the previously established carcinogenic responses i...

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Hoofdauteurs: Shorey, Lyndsey, Castro, David J., Baird, William, Siddens, Beth, Löhr, Christiane, Matzke, Melissa, Waters, Katrina M., Corley, Richard A., Williams, David E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2011
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3269513/
https://ncbi.nlm.nih.gov/pubmed/22085489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2011.11.010
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