CD34(+)/CD38(−) stem cells in chronic myeloid leukemia express Siglec-3 (CD33) and are responsive to the CD33-targeting drug gemtuzumab/ozogamicin

BACKGROUND: CD33 is a well-known stem cell target in acute myeloid leukemia. So far, however, little is known about expression of CD33 on leukemic stem cells in chronic leukemias. DESIGN AND METHODS: We analyzed expression of CD33 in leukemic progenitors in chronic myeloid leukemia by multi-color fl...

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Hlavní autoři: Herrmann, Harald, Cerny-Reiterer, Sabine, Gleixner, Karoline V., Blatt, Katharina, Herndlhofer, Susanne, Rabitsch, Werner, Jäger, Eva, Mitterbauer-Hohendanner, Gerlinde, Streubel, Berthold, Selzer, Edgar, Schwarzinger, Ilse, Sperr, Wolfgang R., Valent, Peter
Médium: Artigo
Jazyk:Inglês
Vydáno: Ferrata Storti Foundation 2012
Témata:
Original Articles and Brief Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3269481/
https://ncbi.nlm.nih.gov/pubmed/21993666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2010.035006
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