Hydroxynonenal-Generated Crosslinking Fluorophore Accumulation in Alzheimer Disease Reveals a Dichotomy of Protein Turnover

Lipid peroxidation generates reactive aldehydes, most notably hydroxynonenal (HNE), which covalently bind amino acid residue side chains leading to protein inactivation and insolubility. Specific adducts of lipid peroxidation have been demonstrated in intimate association with the pathological lesio...

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Detalhes bibliográficos
Main Authors: Zhu, Xiongwei, Castellani, Rudy J., Moreira, Paula I., Aliev, Gjumrakch, Shenk, Justin C., Siedlak, Sandra L., Harris, Peggy L.R., Fujioka, Hisashi, Sayre, Lawrence M., Szweda, Pamela A., Szweda, Luke I., Smith, Mark A., Perry, George
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3268699/
https://ncbi.nlm.nih.gov/pubmed/22137893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2011.11.004
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