Inhibition of Signal Transducer and Activator of Transcription 3 (STAT3) Attenuates Interleukin-6 (IL-6)-induced Collagen Synthesis and Resultant Hypertrophy in Rat Heart

IL-6 has been shown to play a major role in collagen up-regulation process during cardiac hypertrophy, although the precise mechanism is still not known. In this study we have analyzed the mechanism by which IL-6 modulates cardiac hypertrophy. For the in vitro model, IL-6-treated cultured cardiac fi...

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Detalhes bibliográficos
Main Authors: Mir, Saiful Anam, Chatterjee, Arunachal, Mitra, Arkadeep, Pathak, Kanchan, Mahata, Sushil K., Sarkar, Sagartirtha
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3268425/
https://ncbi.nlm.nih.gov/pubmed/22157761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.246173
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