Digoxin inhibits development of hypoxic pulmonary hypertension in mice

Chronic hypoxia is an inciting factor for the development of pulmonary arterial hypertension. The mechanisms involved in the development of hypoxic pulmonary hypertension (HPH) include hypoxia-inducible factor 1 (HIF-1)–dependent transactivation of genes controlling pulmonary arterial smooth muscle...

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Detalhes bibliográficos
Main Authors: Abud, Edsel M., Maylor, Julie, Undem, Clark, Punjabi, Arjun, Zaiman, Ari L., Myers, Allen C., Sylvester, J. T., Semenza, Gregg L., Shimoda, Larissa A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3268303/
https://ncbi.nlm.nih.gov/pubmed/22232678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1120385109
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