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Digoxin inhibits development of hypoxic pulmonary hypertension in mice

Chronic hypoxia is an inciting factor for the development of pulmonary arterial hypertension. The mechanisms involved in the development of hypoxic pulmonary hypertension (HPH) include hypoxia-inducible factor 1 (HIF-1)–dependent transactivation of genes controlling pulmonary arterial smooth muscle...

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Autors principals: Abud, Edsel M., Maylor, Julie, Undem, Clark, Punjabi, Arjun, Zaiman, Ari L., Myers, Allen C., Sylvester, J. T., Semenza, Gregg L., Shimoda, Larissa A.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3268303/
https://ncbi.nlm.nih.gov/pubmed/22232678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1120385109
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