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Evaluation of an approximation method for assessment of overall significance of multiple dependent tests in a genome wide association study
We describe implementation of a set-based method to assess the significance of findings from genome-wide association study data. Our method, implemented in PLINK, is based on theoretical approximation of Fisher’s statistics such that the combination of p-vales at a gene or across a pathway are done...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3268180/ https://ncbi.nlm.nih.gov/pubmed/22006681 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gepi.20636 |
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