Evaluation of an approximation method for assessment of overall significance of multiple dependent tests in a genome wide association study

We describe implementation of a set-based method to assess the significance of findings from genome-wide association study data. Our method, implemented in PLINK, is based on theoretical approximation of Fisher’s statistics such that the combination of p-vales at a gene or across a pathway are done...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Moskvina, Valentina, O’Dushlaine, Colm, Purcell, Shaun, Craddock, Nick, Holmans, Peter, O’Donovan, Michael C
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2011
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3268180/
https://ncbi.nlm.nih.gov/pubmed/22006681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gepi.20636
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