Caricamento...

Synthesis, Crystal Structure, and Rotational Energy Profile of 3-Cyclopropyl-1,2,4-benzotriazine 1,4-Di-N-oxide

1,2,4-Benzotriazine 1,4-di-N-oxides are potent antitumor drug candidates that undergo in vivo bioreduction leading to selective DNA damage in the low oxygen (hypoxic) cells found in tumors. Tirapazamine (TPZ) is the lead compound in this family. Here we report on the synthesis, crystal structure, an...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Sarkar, Ujjal, Glaser, Rainer, Parsons, Zack D., Barnes, Charles L., Gates, Kent S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3268128/
https://ncbi.nlm.nih.gov/pubmed/22294856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10870-010-9707-9
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !