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Biochemical identification of a hydroperoxide derivative of the free 8-oxo-7,8-dihydroguanine base
8-Oxo-7,8-dihydroguanine is one the most abundant base lesions in pro- and eukaryotic DNA. In mammalian cells, it is excised by the 8-oxoguanine DNA glycosylases (OGG1) during DNA base excision repair, and the generated free 8-oxoG base (8-oxoG) is one of the DNA-derived biomarkers of oxidative stre...
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| Auteurs principaux: | , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3267897/ https://ncbi.nlm.nih.gov/pubmed/22198182 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2011.11.015 |
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