BMP-9 Induced Endothelial Cell Tubule Formation and Inhibition of Migration Involves Smad1 Driven Endothelin-1 Production

BACKGROUND: Bone morphogenetic proteins (BMPs) and their receptors, such as bone morphogenetic protein receptor (BMPR) II, have been implicated in a wide variety of disorders including pulmonary arterial hypertension (PAH). Similarly, endothelin-1 (ET-1), a mitogen and vasoconstrictor, is upregulate...

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Bibliografski detalji
Glavni autori: Park, John E. S., Shao, Dongmin, Upton, Paul D., deSouza, Patricia, Adcock, Ian M., Davies, Rachel J., Morrell, Nicholas W., Griffiths, Mark J. D., Wort, Stephen J.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3267722/
https://ncbi.nlm.nih.gov/pubmed/22299030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030075
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