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Misalignment of V and J gene segments resulting in a nonfunctional immunoglobulin gene.
The myeloma variant NS-1n has lost the functional immunoglobulin kappa gene which is present in its parent, myeloma MOPC-21. The variant retains a nonfunctional rearranged gene, M.21N, which undergoes RNA transcription and processing to yield a mature size kmRNA. This kRNA, however, is not translate...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
1981
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| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC326739/ https://ncbi.nlm.nih.gov/pubmed/6164985 |
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