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Distinct evolutionary strategies of human leucocyte antigen loci in pathogen-rich environments

Human leucocyte antigen (HLA) loci have a complex evolution where both stochastic (e.g. genetic drift) and deterministic (natural selection) forces are involved. Owing to their extraordinary level of polymorphism, HLA genes are useful markers for reconstructing human settlement history. However, HLA...

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Detalhes bibliográficos
Main Authors: Sanchez-Mazas, Alicia, Lemaître, Jean-François, Currat, Mathias
Formato: Artigo
Idioma:Inglês
Publicado em: The Royal Society 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3267122/
https://ncbi.nlm.nih.gov/pubmed/22312050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2011.0312
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