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Biochemical Discrimination between Selenium and Sulfur 2: Mechanistic Investigation of the Selenium Specificity of Human Selenocysteine Lyase

Selenium is an essential trace element incorporated into selenoproteins as selenocysteine. Selenocysteine (Sec) lyases (SCLs) and cysteine (Cys) desulfurases (CDs) catalyze the removal of selenium or sulfur from Sec or Cys, respectively, and generally accept both substrates. Intriguingly, human SCL...

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Main Authors: Johansson, Ann-Louise, Collins, Ruairi, Arnér, Elias S. J., Brzezinski, Peter, Högbom, Martin
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266904/
https://ncbi.nlm.nih.gov/pubmed/22291978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030528
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