Imiquimod clears tumors in mice independent of adaptive immunity by converting pDCs into tumor-killing effector cells

Imiquimod is a synthetic compound with antitumor properties; a 5% cream formulation is successfully used to treat skin tumors. The antitumor effect of imiquimod is multifactorial, although its ability to modulate immune responses by triggering TLR7/8 is thought to be key. Among the immune cells sugg...

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Главные авторы: Drobits, Barbara, Holcmann, Martin, Amberg, Nicole, Swiecki, Melissa, Grundtner, Roland, Hammer, Martina, Colonna, Marco, Sibilia, Maria
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2012
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266798/
https://ncbi.nlm.nih.gov/pubmed/22251703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI61034
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