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Imiquimod clears tumors in mice independent of adaptive immunity by converting pDCs into tumor-killing effector cells
Imiquimod is a synthetic compound with antitumor properties; a 5% cream formulation is successfully used to treat skin tumors. The antitumor effect of imiquimod is multifactorial, although its ability to modulate immune responses by triggering TLR7/8 is thought to be key. Among the immune cells sugg...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Clinical Investigation
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3266798/ https://ncbi.nlm.nih.gov/pubmed/22251703 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI61034 |
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